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Effects of 12-Week Dietary Inflammatory Index-Based Dietary Education on Frailty Status in Frail Patients with Colorectal Cancer: A Randomized Controlled Trial

12周饮食炎症指数为基础的饮食教育对衰弱结直肠癌患者衰弱状态的影响：一项随机对照试验

colorectal cancer; dietary education; dietary inflammatory index; frailty; inflammation.

结直肠癌；饮食教育；饮食炎症指数；衰弱；炎症

Frailty is common in colorectal cancer (CRC) patients and is associated with poor prognosis and increased mortality. Anti-inflammatory dietary education is a promising and cost-effective strategy for frailty improvement.

衰弱在结直肠癌（CRC）患者中很常见，并与预后不良和死亡率增加有关。抗炎饮食教育是改善衰弱的一种有前途和成本效益的策略。

A prospective, assessor-blinded, two-arm randomized controlled trial was conducted to assess the effects of a 12-week dietary inflammatory index (DII)-based anti-inflammatory dietary education program on frailty in frail CRC patients. Participants in the intervention group received a DII-based anti-inflammatory dietary education, while the control group received a routine health education. Outcome measurements included the Fried frailty phenotype (FP), DII, plasma inflammatory biomarkers, body mass index (BMI), nutritional status, and quality of life (QoL), which were all assessed at baseline and post-intervention.

一项前瞻性、评审盲、两组随机对照试验旨在评估为期12周的基于饮食炎症指数（DII）的抗炎饮食教育计划对衰弱CRC患者衰弱的影响。干预组接受基于DII的抗炎饮食教育，对照组接受常规健康教育。结果测量包括Fried衰弱表型（FP）、DII、血浆炎症生物标志物、体重指数（BMI）、营养状况和生活质量（QoL），这些都是在基线和干预后评估的。

A total of 86.4% (57/66) of participants completed the follow-up. No statistically significant baseline differences were observed between groups. After the intervention, the intervention group showed significant improvements in DII (p = 0.029), BMI (p = 0.012), mini nutritional assessment (MNA) scores (p = 0.027), and QoL (p = 0.014) compared with the control group. Within-group comparisons revealed significant decreases in frailty status (p = 0.031), DII (p = 0.008), and interleukin (IL)-6 (p = 0.003), and significant increases in IL-10 (p = 0.021), MNA scores (p = 0.010), and QoL (p < 0.001) in the intervention group, with no significant changes in the control group.

共有86.4%（57/66）的参与者完成了随访。各组间基线差异无统计学意义。干预后，干预组在DII （p = 0.029）、BMI （p = 0.012）、mini nutrition assessment （MNA）评分（p = 0.027）、QoL （p = 0.014）方面均较对照组有显著改善。组内比较显示，干预组的衰弱状态（p = 0.031）、DII （p = 0.008）和白细胞介素(IL)-6 （p = 0.003）显著降低，IL-10 （p = 0.021）、MNA评分（p = 0.010）和生活质量（p < 0.001）显著升高，对照组无显著变化。

DII-based anti-inflammatory dietary education can improve the frailty, nutritional status, and QoL of frail CRC patients by modulating systemic inflammation. Given its acceptability and utility, this strategy may be incorporated into routine cancer health education.

以DII为基础的抗炎饮食教育可通过调节全身炎症改衰弱型结直肠癌患者的衰弱、营养状况和生活质量。鉴于其可接受性和实用性，该策略可纳入常规癌症健康教育。